NEUROMETABOLOMICS RESEARCH CENTER
"We aim at developing diagnosis and treatment for metabolism-related neurological disorders by identifying new targets in regulation of metabolism in neurons and tissues using neurometabolomics approach by establishment of Neurometabolomics Research Center (NRC) at DGIST"
뇌대사체학연구센터는 DGIST의 세계적인 뇌대사학 선도 연구능력을 바탕으로,
Agilent Technologies의 세계 최고의 분석 장비 및 기술력, 존스홉킨스 대학
비만대사 연구소의 축적된 연구역량 그리고 대구시의 대학병원과 첨복사업 등 강점분야인
의료 인프라를 결집해 미국·싱가포르·호주·한국 간의 뇌대사체학 국제공동연구를
기반으로 단기간에 세계적인 의료 선도센터로 성장하여 국·내외 뇌대사체 연구
전문가 인력 양성과 질병 조기진단 융복합 기술 제공을 목표로 합니다.
Director
Eun-Kyoung Kim
Research Objectives
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The NRC aims to provide integrated technology for fostering expertise in brain metabolism research and early disease diagnosis, based on DGIST's world-leading brain metabolism research capabilities, Agilent Technologies' cutting-edge analytical equipment and technology, the accumulated research expertise from the Johns Hopkins Center for Metabolism and Obesity Research, convergence of medical infrastructure with domestic university hospitals, and international collaborative research in brain metabolism among the United States, Singapore, and Australia.
Interests
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Developing analysis techniques to measure brain metabolites and conducting basic biological research to comprehensively interpret complex brain metabolism
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Investigating neural-based metabolic mechanisms in metabolic diseases such as obesity and diabetes, and neurodegenerative diseases
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Developing early diagnostic technologies for specific diseases and discovering biomarkers to suggest the causes and treatments
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Evaluating drug responses in various diseases and suggesting mechanisms or treatment strategies by identifying specific metabolites or metabolic pathways
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Building libraries to process and classify metabolite-based metadata using bioinformatics, statistics, and computer engineering
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뇌대사체를 측정하는 분석기술 개발과 복잡한 뇌대사체의 종합적 해석을 위한 기초과학 연구수행
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비만, 당뇨, 뇌질환 (치매, 퇴행성뇌질환) 등의 대사질환에서의 신경기반 대사 기전 연구
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특정 질환의 조기 진단 기술 개발 및 발병 원인과 치료법 제시를 위한 바이오마커 발굴
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다양한 질환에서의 약물 반응 평가 및 특이적 대사체/대사경로 선별 후 기전 및 치료법 제시
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생물정보학, 통계학, 컴퓨터 공학 등을 사용하여 대사체 기반 메타데이터 처리 및 분류 후 라이브러리 구축
Facilities
DGIST E4-320B, 333, Techno jungang-daero, Hyeonpung-eup, Dalseong-gun
Daegu, Republic of Korea
Agilent 1290 and Agilent 6530
UPLC-QTOF-MS/MS
Agilent 1290 and Agilent 6490
UPLC-triple quad-MS/MS
Agilent 7890B and Agilent 7000C
GC-triple quad-MS/MS
History
2012.07 Agilent Technologies와 MOU 체결
2013.02 연세대 세브란스 병원과 MOU 체결
2013.06 글로벌교류협력사업 선정 (대구연구개발특구본 부)
2013.07 존스홉킨스대학 비만대사 연구소와 연구협력
2013.07 존스홉킨스대학 Center of Excellence와 공동연구
2013.07 뇌대사체학 연구센터 사업 선정 (DGIST)
2013.08 뇌과학원천기술개발사업 선정 (미래창조과학부/한국연구재단)
2013.10 뇌대사체학 연구센터 설립 (산학협력관)
2014.01 대사성 뇌질환 공동연구 세미나 개최
2014.03 싱가포르국립대학 SLING center와 연구협력
2014.10 뇌대사체학 연구센터 교육동 (E4-320) 이전
Center Members
Works
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Analyzable samples: bio-samples (blood, CSF, tissues, urine, cells)
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Platforms: untargeted or targeted LC/GC-MS/MS
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Analysis: identification/quantification of metabolites in samples, analytical method developments, discovery of biomarker for diseases, measurement of clinical efficacy, etc.
공동연구 의뢰
대사체학분석을 위한 공동연구는 연구 계획 및 내용을 협의하여 진행합니다.
자세한 사항은 뇌대사체학연구센터장 메일 (ekkim@dgist.ac.kr)을 통해 문의바랍니다.
공동연구 기관
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대학기관: 서울대학교, 고려대학교, 아주대학교, 연세대학교, 성균관대학교, GIST, POSTECH, KIOST
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의료기관: 서울아산병원, 아주대학교병원, 부산대학교병원
Publications (Metabolomics applications)
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Park, S., and Kim, E.-K. (2024) Machine Learning-Based Plasma Metabolomics in Liraglutide-Treated Type 2 Diabetes Mellitus Patients and Diet-Induced Obese Mice. Metabolites 14(9) 483
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Park, S., Oh, S., Kim, N., and Kim, E.-K. (2023) HMBA ameliorates obesity by MYH9- and ACTG1-dependent regulation of hypothalamic neuropeptides. EMBO Molecular Medicine 15(12) e18024
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Park, S., Oh, S., and Kim, E.-K. (2022) Glucagon-like peptide-1 analog liraglutide leads to multiple metabolic alterations in diet-induced obese mice. Journal of Biological Chemistry 298(12):102682
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Jeon, Y.J., Lim, Y., Yeom, J., and Kim, E.-K. (2021) Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory. Molecular Brain 14:153
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Choi, Y., Song, M.-J., Jung, W.-J., Jeong, H., Park, S., Yang, B., Lee, E.-C., Joo, J.-S., Choi, D., Koo, S.-H., Kim, E.-K., Nam, K.T., and Kim, H.-P. (2021) Liver-specific deletion of mouse CTCF leads to hepatic steatosis via augmented PPARg signaling. Cellular and Molecular Gastroenterology and Hepatology 12(5):1761-1787
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Jo, C., Park, S., Oh, S., Choe, J., Kim, E.-K., Youn, H.-D., and Cho, E.-J. (2020) Histone acylation marks respond to metabolic perturbations and enable cellular adaptation. Experimental and Molecular Medicine 52:2005-2019
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Kim, S., Kim, N., Park, S., Jeon, Y., Lee, J., Yoo, S.-J., Lee, J.-W., Moon, C., Yu, S.-W., and Kim, E.-K. (2020) Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. Autophagy 16(7):1200-1220
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Park, S., Oh, T.S., Kim, S., and Kim, E.-K. (2019) Palmitate-induced autophagy liberates monounsaturated fatty acids and increases Agrp expression in hypothalamic cells. Animal cells and systems 23(6):384-391
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Lee, J.-W., Nam, H., Kim, L.E., Jeon, Y.J., Min, H., Ha, S., Lee, Y., Kim, S.-Y., Lee, S.J., Kim, E.-K., and Yu, S.-W. (2019) Toll-like receptor 4 activation suppresses autophagy through inhibition of FoxO3 and impairs phagocytic capacity of microglia. Autophagy 15(5):753-770
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Park, S., Sadanala, K.C., and Kim, E.-K. (2015) A metabolomics approach to understanding the metabolic link between obesity and diabetes. Molecules and Cells 38(7): 587-596
지식재산권 (특허등록)
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국내특허, 뇌 시상하부 세포에서 TSPO에 의한 대사체 변화 분석방법
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3종 이상을 포함하는 신경전달물질의 동시 분석 방법
Open Positions
Welcome to join the lab, Research technicians and Graduate students
We are looking for applicants who are responsible and reliable, who have passion and
strong motivation about scientific research with backgrounds in biological chemistry
If you are interested in joining our lab, please send your CV with a short biography
to introduce yourself to ekkim@dgist.ac.kr
